米兰

研究活动

从1982年IFC-CNR就在米兰Niguarda医院内部有战略性的位置(协议续期2015-2020)，除了在心血管范围有历史性的活动路线（如心力衰竭，移植及机械辅助，心胸血管系，心血管系就是这些领域的意大利的基准点），给了继续实行先进临床研究的机会，施行多学科综合性合作，甚至在其它领域（老龄化，人口脆弱，神经及代谢障碍...) 进行研究，更提供制度化辅助活动的不可缺少的一部分（为医院做化验室检验)。IFC的生物医学研究人员可以协助临床研究项目（临床实验，及传染病学研究），因为米兰的Niguarda第二分局是临床及辅助研究单位。

参加了框架计划FP6/FP7项目以及目前参加了H2020的欧洲研究合作者以米兰分局为公认的有特别专长及经验的CNR机构。这部门更是CNR米兰与帕维亚的机构在CNR-伦巴第大区的框架计划范围内的转化研究临床中心。这部门与其它五间伦巴第大区内与生物医学系有关联的学院 (IBFM, IGM, ITB, IN, IRGB) ，以及与化学科学及材料技术系有关联的分子识别化学学院(ICRM)，被插入伦巴第大区的生命科学的技术集群里。以这背景，这部门以转化研究临床中心的性质参加了CNR–伦巴第大区的2014-2015 框架计划内MbMM 项目(多因子病症的诊断及治疗的先进方法基础），及CARE-G (老年市民的健康护理及生活质量服务平台：评估与新科技的互动），目前参与2016-2018框架计划内AMANDA 项目（与代谢障碍相关的神经变性的基础细胞和分子机理的研究)。

最近IFC-MI的分局被选为意大利临床中心，进行多中心试验MAST4HEALTH 项目– Mastiha医疗诊断有NAFLD（非酒精性脂肪性肝病）的健康性肥胖人士, 为EU Horizon 2020 范围内MSCA GA 691042, Marie Sklodowska-Curie Actions (MSCA) Research and Innovation Staff Exchange (RISE) 的计划 [多中心临床随机化，双盲，安慰剂对照（并联臂）研究对肥胖人士用Mastiha来治疗的效果，诊断非酒精性肝性脂肪变性(NAFLD/NASH（非酒精性脂肪性肝炎）)]。

研究范围：风险因子，血管内皮功能障碍，营养学及营养制品，动脉硬化，心力衰竭, [从无临床症状的阶段直至到晚期心力衰竭（CRT – Cardiac Resynchronization Therapy 心脏再同步化治疗）及难治性心力衰歇 (LVAD-Left Ventricular Assist Device 左心室辅助装置及TxC-心脏移植)], 脓毒症，神经性退化（CADASIL arteriopatia cerebrale autosomica dominante 常染色体显性脑动脉病症, 帕金森症）。病理生理变量与污染物质或气候变量的互动（研究健康-坏境关系）。

特别技能： 1. 临床：设计，准备及监测临床实验；处理介绍伦理委员会研究的程序；使用非创伤性技术专为参加临床研究协议的人士做心血管，植物神经系统及营养学的诊所评估。 2. 研究室：评估血及氧化应激组织内生物标志物, 抗氧化能力，发炎，内皮激活，纤维变性症及维生素营养状态（维生素A，E， C， B 胡萝卜素, B1, B2, B6)；血液样品及有特别miRNA组织样品内的分子生物学，基因表现及遗传性变形。3. 统计：支持临床-生物研究协议规定的方法以及相关统计计算。

功能研究技术

身体组成：生物电抗阻分析法（体脂肪测定分析仪器）， Bod-Pod 身体测量仪，量热法

植物性神经系统功能：用心电图及软件来评估心率变异性（HRV）

-外围内皮功能: 体积描记法 Endo-PAT2000

-嗅觉功能：嗅探棒延长测试

循环生物标志的生物化学研究:

-高效液相色谱法 (HPLC)

-电泳疗法

-蛋白免疫印迹法

-酶联免疫吸附试验（ELISA 及 EIA)

分子生物学研究:

-循环变温加热器

监测研究:

-可佩戴的多参数资料生物医学装置

PROGETTI & PROPOSTE 2017

1)BLUEMOON

BioImpedentiometry and Lung Ultrasound Examination to MOnitor cONgestion in Heart

Failure. In corso, approvato dal Comitato Etico, in collaborazione con Dottoressa Maria Frigerio e Professoressa Cristina Giannattasio. ClinicalTrials.gov ID: NCT02394470 ClinicalTrials.gov Protocol and Results Registration System (PRS) Receipt Release Date: 01/16/2016.

2)SKIM LEAN

Systematic laboratory Knowledge Integration for Management of Lipid Excess in high-risk pAtieNts

Approvato e finanziato PFIZER. Capofila Prof.ssa Laura Calabresi del Centro Enrica Grossi Paoletti Università degli Studi di Milano, partner IFC-CNR UOS Milano, Dott.ssa Antonia Alberti (SSD Diagnosi e Cure Territoriali Mal. Cardiache), Ing. Gianni Origgi ICT Niguarda, NoemaLIfe.

3)MAST4HEALTH

Mastiha treatment for healthy obese with NAFLD diagnosis

Progetto H2020, Marie Curie, partner di Consorzio IFC-CNR Grant Agreement n. 691042 — MAST4HEALTH — H2020-MSCA-RISE-2015/H2020-MSCA-RISE-2015, UOS-MI proponente studio clinico in collaborazione con Prof. Vanzulli (SC Radiologia) e Dott. Belli (SC Gastroenterologia ed Epatologia). Clearance CNR (approvazione della Commissione per l’Etica della Ricerca e la Bioetica del CNR) ottenuta a Febbraio 2016. Documenti presentati al Comitato Etico, in attesa di risposta.

4)SleSOB

Sleep disturbances and biomarkers of sarcopenic obesity: insight into mechanisms of prefrailty

Proposta Bando CARIPLO 2017, in collaborazione con Dott. Nobili (SS Medicina del Sonno, Ospedale Niguarda) e Dott. Corradi (SC Nutrizione Clinica, Ospedale Niguarda). Capofila IFC-CNR UOS-Milano.

5)VAD patient data (from SensorART, FP7Large-scale integrating project (IP) -FP7-ICT-2009-4 Project No. 248763 )

Collaborazione con Dottoressa Maria Frigerio e con Prof. Zoran Obradovic ,Temple University Philadelphia, PA, Director, Center for Data Analytics and Biomedical Informatics. Collaborazione scientifica in funzione di possibile applicazione a Grant (NIH programs).

6)Trapianti dopo espianto mantenuto a cuore battente

Collaborazione scientifica con Dott. Claudio Russo (SC Cardiochirurgia): analisi dati. Ricerca Scientifica

Proposta di progetto in corso di definizione

Trapianto di cuore: studio della perfusione cardiaca , del metabolismo miocardico e dello stato infiammatorio per verifica degli effetti del dispositivo Transmedics su cuori espiantati “battenti”.

7)PERCEVAL

PERCeived VALue of TECHnological health SERvices (PERCEVAL TECH-SER)

Progetto di valutazione di usabilità , accettabilità e impatto sulla qualità di vita di nuove tecnologie sanitarie. Progetto concluso nella prima fase, in stesura il manoscritto. Prospettive di ulteriori attività in ambito ICT e telemedicina.

8)DISCASS

Studio della DISfunzione Cardiovascolare nei pazienti con Shock Settico.

IFC UOS Milano (partner) si occupa dell’identificazione di biomarcatori circolanti predittori di disfunzione cardiaca e outcome negativo in pazienti affetti da shock settico.

In collaborazione con Dipartimento Cardiotoracovascolare Niguarda e Università degli Studi Milano Bicocca (Prof. ssa Giannattasio); Anestesia e Rianimazione 2 Niguarda (Dott. De Gasperi); Anestesia e Rianimazione 1 Niguarda (Prof. Fumagalli).

9)AMANDA

Alterazioni MetAboliche, stress cellulari e processi NeuroDegenerAtivi

Studio dei meccanismi cellulari e molecolari alla base della neurodegenerazione correlata ad alterazioni metaboliche.

Cofinanziamento CNR-Regione Lombardia.

IFC-CNR UOS Milano partner in collaborazione con altri 6 istituti del CNR Lombardo (IBFM, IGM, IN, IRGB, ITB, ICRM). Collaborazione Dott. Corradi (SC Nutrizione Clinica, Ospedale Niguarda).

10)SEMEOTICONS

SEMEiotic Oriented Technology for Individual’s CardiOmetabolic risk self-assessmeNt and Self-monitoring FP7-ICT-2013-10, Grant agreement no: 611516

Sviluppo e validazione di un sistema personalizzato, non intrusivo di facile uso, per l’autogestione dello stile di vita e la prevenzione delle malattie cardiometaboliche in soggetti sani.

ISTI-CNR Coordinatore in collaborazione con IFC-CNR Pisa e Milano; Foundation For Research And Technology Hellas, Greece; Linkopings Universitet, Sweden; University Of Central Lancashire, UK; Norges Teknisk-Naturvitenskapelige Universitet Ntnu, Norway; Centre De Recherche En Nutrition Humaine Rhone-Alpes, France; INTECS SPA, Italy; Hellenic Telecommunications & Telematics Applications Company, Greece; Draco Systems SL, Spain; COSMED SRL, Italy. IFC UOS Milano come sede secondaria di validazione dispositivo; altra sede IFC Pisa. In corso analisi dati. Progetto concluso.

11)Studio dell’equilibrio cellulare e dello stress ossidativo nella pratica sportiva estrema

Valutazione dello stato redox dei tioli della capacità antiossidante e dei danni indotti dalla formazione di ROS prima e dopo gare di ultramaratona.

IFC-CNR Pisa e UOS Milano (partners) in collaborazione con IBFM-CNR; Università degli Studi di Milano (Prof.ssa Bamonti).

12) Consumo di sostanze psicoattive e gioco d'azzardo tra gli studenti della provincia di Bergamo
Monitoraggio della popolazione studentesca (15-19 anni) attraverso il sovracampionamento provinciale nell'ambito dello studio ESPAD®Italia. Progetto in corso, in fase di realizzazione e di stesura il rapporto tecnico scientifico conclusivo, nel quale saranno riportate le principali evidenze emerse dalle attività di ricerca condotte. Responsabile scientifico: dott.ssa Sabrina Molinaro, IFC Pisa.

13)Biomarcatori nella pre-eclampsia. Progetto in fase di proposta. Capofila Prof.ssa Cristina Giannattasio.

Studio della pressione arteriosa delle 24 ore e della funzione vascolare in donne in gravidanza ad elevato rischio di sviluppare pre-eclampsia (in sottomissione ANMCO 2017).

米兰

IFC-CNR Milan site (UOS-Milano) is located since 1983 within ASST-Great Metropolitan Hospital Niguarda, where it acts as Clinical Research and Care Unit of the CardioThoracic and Vascular Department through an ad hoc agreement and its clinical research center.
IFC-CNR UOS Milan has past and ongoing research collaborations with the different hospital departments. Main research topics include cardiovascular pathophysiology and endothelium-mediated vasodilation, oxidative stress and atherosclerotic damage, the identification and validation of novel biomarkers, heart failure and mechanical circulatory support, clinical trial methodology and virtual pathology.
Besides research activities, the Clinical Biochemistry Laboratory at IFC-CNR UOS Milan performs as clinical service laboratory assays for plasma homocysteine, cysteine and glutathione, urinary cystein, blood vitamins B1, B2, and serum vitamins A, E, C, beta-carotene and B6, biomarkers of inflammation, extracellular matrix activity and macrophage activation (cytokines, neopterin, metalloproteases, etc), plasma and tissue microRNA assays.
IFC-CNR UOS-Milano features a dedicated outpatient clinic for clinical data collection, nutritional evaluation and the non-invasive assessment of cardiovascular and autonomic nervous system function devoted to subjects enrolled in clinical protocols. Special attention is paid to community care, social integration with health care and health and environment topics under the Smart Cities development strategy.
Multidisciplinary and translational research towards Systems Biology and Medicine are main lines of past, present and future interest of UOS Milan as well as IFC as a whole.
The competence and expertise of IFC-CNR UOS Milan personnel allow to project and carry out multidisciplinary research activities in numerous research fields: cardiovascular biomarkers/cardiac imaging/heart failure/mechanical circulatory support/ischemic heart disease/prevention/ICT Health/multifactorial diseases/cardiovascular system and nutrition/epidemiology.

工作人员

HEAD RESEARCHER
Rosa Sicari	该 Email 地址已受到反垃圾邮件插件保护。要显示它需要在浏览器中启用 JavaScript。
PERSONNNEL
Campolo Jonica (Ricercatore)	该 Email 地址已受到反垃圾邮件插件保护。要显示它需要在浏览器中启用 JavaScript。
De Maria Renata (Ricercatore assegnista)	该 Email 地址已受到反垃圾邮件插件保护。要显示它需要在浏览器中启用 JavaScript。
Di Guglielmo Maria Luisa (Ricercatore assegnista)
Dellanoce Cinzia (Tecnico laboratorio)	该 Email 地址已受到反垃圾邮件插件保护。要显示它需要在浏览器中启用 JavaScript。
Parolini Marina (Tecnico Statistica)	该 Email 地址已受到反垃圾邮件插件保护。要显示它需要在浏览器中启用 JavaScript。
Luppi Claudia (Tecnico Epidemiologia)	该 Email 地址已受到反垃圾邮件插件保护。要显示它需要在浏览器中启用 JavaScript。
SECRETARIAT
Spagnolo Elisabetta	该 Email 地址已受到反垃圾邮件插件保护。要显示它需要在浏览器中启用 JavaScript。
CONTACTS
Telefono	02/64442605 – 02/6473407
Fax	02-66116990

科学生产

• Sedda V, De Chiara B, Parolini M, Caruso R, Campolo J, Cighetti G, De Maria R, Sachero A, Donato L, Parodi O. Plasma glutathione levels are independently associated with g-glutamyltransferase activity in subjects with cardiovascular risk factors. Free Radical Res 2008;42:135-41. doi: 10.1080/10715760701836821.

• Redaelli R, Corno AR, Somaini MG, Gechtman C, Caimi TM, Baudo F, Morra E. False incoagulabile PT-INR results in oral anticoagulant therapy. Thromb Res 2008;122:137-39.

• Vesentini N, Kusmic C, Battaglia D, Taddei MC, Parodi O, Palombo C, Paolicchi A, Barsacchi R. Modulation of erythrocyte sensitivity to oxidative stress by transient hyperhomocysteinemia in healthy subjects and in patients with coronary artery disease. Nutr Met Cardiovasc Dis 2008,18:402-07.

• Mazzoni M, Bortone F, Ceriani R, Caprioli G, Passaretti B, Arena V, Parodi O. Metabolism of hibernating myocardium assessed by microdialysis during surgical revascularization. J Card Surg 2008; 23:374-76. doi: 10.1111/j.1540-8191.2008.00572.x. Epub 2008 Jul 1.

• Campolo J, Sedda V, De Maria R, Caruso R, Parolini M, Bianchi M, Girola D, Parodi O. Redox state alteration and endothelial dysfunction. Il Patologo clinico 2008;27-30.

• Neglia D, Parodi O. Detecting the impact of emerging cardiovascular risk factors: the role of positron emission tomography. J Nucl Cardiol 2008;15:485-90. doi: 10.1016/j.nuclcard.2008.05.009.

• Caruso R, Trunfio S, Milazzo F, Campolo J, De Maria R, Colombo T, Parolini M, Cannata A, Russo C, Paino R, Frigerio M, Martinelli L, Parodi O. Early expression of Pro-and Anti-Inflamamtory Cytokines in Left Ventricular Assist Device Recipients with Multi-Organ Failure Syndrome. ASAIO J 2010;56:313-18. doi: 10.1097/MAT.0b013e3181de3049.

• Vergara C, Ponzini R, Veneziani A, Redaelli A, Neglia D, Parodi O. Womersley number-based estimation of flow rate with Doppler ultrasound: Sensitivity analysis and first clinical application. Comput Meth Progr Bio 2010;98:151-60. doi: 10.1016/j.cmpb.2009.09.013. Epub 2009 Oct 29.

• Ponzini R, Vergara C, Rizzo G, Veneziani A, Roghi A, Vanzulli A, Parodi O, Redaelli A. Womersley number-based estimates of blood flow rate in Doppler analysis: In vivo validation by means of Phase Contrast Magnetic Resonance Imaging. IEEE T Biomed Eng 2010;57:1807-15. doi: 10.1109/TBME.2010.2046484.

• Corno AR, Campolo J, Redaelli R, Nichelatti M. Automated APTT cycle for the rapid identification of plasma prekallikrein deficiency. Letter to the Editors-in-Chief. Thromb Res 2010;126:e152-e153.

• Caiani EG, Redaelli A, Parodi O, Votta E, Maffessanti F, Tripoliti E, Nucifora G,Marchi D, Tarroni G, Lombardi M, Corsi C. Development and Validation of Automated Endocardial and Epicardial Contour Detection for MRI Volumetric and Wall Motion Analysis. Computing in Cardiology 2010;37:1083−86.

• Conti CA, Stevanella M, Maffessanti F, Trunfio S, Votta E, Roghi A, Parodi O, Caiani EG, Redaelli A. Mitral Valve Modelling in Ischemic Patients: Finite Element Analysis from Cardiac Magnetic Resonance Imaging. Computing in Cardiology 2010;37:1059−62.

• Maffessanti F, Stevanella M, Votta E, Lombardi M, Parodi O, de Marchi D, Conti CA, Redaelli A, Caiani EG. Feasibility of a Novel Approach for 3D Mitral Valve Quantification from Magnetic Resonance Images. Computing in Cardiology 2010;37:157−60.

• Corno AR, Redaelli R, Caimi TM, Mostarda G, Caruso R, Morra E. Sample carryover in PT-INR determination Is it an issue in Oral Anticoagulant Therapy control? Letter editor. Thromb Res 2011;127:279-81.

• Lunghi B, Redaelli R, Caimi TM, Corno AR, Bernardi F, Marchetti G. Lettere editor. Novel phenotype and -glutamyl carboxylase mutations in combined deficiency of vitamin K-dependentg coagulationLetter to the editor. Haemophilia 2011;17:822-24.

• McFarlane N, Lin X, Zhao Y, Clapworthy G, Dong F, Redaelli A, Parodi O, Testi D. Visualization and simulated surgery of the left ventricle in the virtual pathological heart of the Virtual Physiological Human. Journal of the Royal Society Interface, published online 30 March2011. doi: 10.1098/rsfs.2010.0040

• Conti CA, Votta E, Corsi C, De Marchi D, Tarroni G, Stevanella M, Lombardi M, Parodi O, Caiani EG, Redaelli A. Left ventricular modelling: a quantitative functional assessment tool based on cardiac magnetic resonance imaging. Interface Focus 2011; published online 23 March. doi: 10.1098/rsfs.2010.0029

• Calvelli L, Accinni R, Gregori D, Dellanoce C, Bamonti F, Vigna L, Schiraldi G, Cossovich A, Chiericozzi M, Scala E, Allegra L. Un questionario rapido ed efficace per la valutazione delle abitudini dietetiche e dello stress ossidativo legato all’alimentazione nei pazienti pneumologi. Prog Nutr 2011;13:55-64.

• Caruso R, Caselli C, Boroni C, Campolo J, Milazzo F, Cabiati M, Russo C, Parolini M, Giannessi D, Frigerio M, Parodi O. Relationship Between Myocardial Redox State and Matrix Metalloproteinase Activity in Patients on Left Ventricular Assist Device Support. Circ J 2011;75:2387-96.

• Siogkas P, Sakellarios A, Exarchos T, Athanasiou L, Karvounis E, Stefanou K, Fotiou E, Fotiadis D, Naka K, Michalis L, Filipovic N, Parodi O. Multi-scale patient-specific artery and atherogenesis models. IEEE T Biomed Eng 2011;54:3464-6.

• Liga R, Marini C, Coceani M, Filidei E, Schlueter M, Bianchi M, Rossi G, Pardini S, Salvatori P, Parodi O, Rovai D, Sambuceti G, Marraccini P, Neglia D. Structural Abnormalities of the Coronary Arterial Wall—in Addition to Luminal Narrowing—Affect Myocardial Blood Flow Reserve. J Nucl Med 2011; 52(11):1704-12. doi: 10.2967/jnumed.111.091009. Epub 2011 Sep 19.

• Pelucchi C, Serraino D, Negri E, Montella M, Dellanoce C, Talamini R, La Vecchia C. The Metabolic Syndrome and Risk of Prostate Cancer in Italy. Ann Epidemiol 2011;21:835-41.

• Senni M, Parrella P, De Maria R, Cottini C, Böhm M, Ponikowski P, Filippatos G, Tribouilloy C, Di Lenarda A, Oliva F, Pulignano G, Cicoira M, Nodari S, Porcu M, Cioffi G, Gabrielli D, Parodi O, Ferrazzi P, Gavazzi A and on behalf of the 3 C-HF Study Investigators. Predicting heart failure outcome from cardiac and comorbid conditions: The 3C-HF score. Int J2013;Feb20;163(2):206-11. doi: 10.1016/j.ijcard.2011.10.071. Epub 2011 Nov 29.

• Caruso R, Verde A, Cabiati M, Milazzo F, Boroni C, Del Ry S, Parolini M, Vittori C, Paino R, Martinelli L, Giannessi D, Frigerio M, Parodi O. Association of pre-operative interleukin-6 levels with Interagency Registry for Mechanically Assisted Circulatory Support profiles and intensive care unit stay in left ventricular assist device patients. J Heart Lung Transplant 2012;31:625-doi: 10.1016/j.healun.2012.02.006. Epub 2012 Mar 3.

• Campolo J, De Maria R, Frontali M, Taroni F, Inzitari D, Federico A, Romano S, Puca E, Mariotti C, Tomasello C, Pantoni L, Pescini F, Dotti MT, Stromillo ML, De Stefano N, Tavani A, Parodi O. Impaired vasoreactivity in mildly disabled CADASIL patients. Neurol Neurosurg Psychiatry 2012;83:268-74. doi: 10.1136/jnnp-2011-300080. Epub 2011 Nov 9.

• Filipovic N, Rosic M, Tanaskovic I, Milosevic Z, Nikolic D, Zdravkovic N, Peulic A, Kojic MR, Fotiadis DI, Parodi O. ARTreat Project: Three-Dimensional Numerical Simulation of Plaque Formation and Development in theIEEE Trans Inf Technol Biomed. 2012 Mar;16(2):272-78. doi: 10.1109/TITB.2011.2168418. Epub 2011 Sep 19.

• De Chiara B, Sedda V, Parolini M, Campolo J, De Maria R, Caruso R, Pizzi G, Disoteo O, Dellanoce C, Corno AR, Cighetti G, Parodi O. Plasma total cysteine and cardiovascular risk burden: action and interaction. ScientificWorldJournal. 2012;2012:303654. Epub 2012 Apr 19. doi:10.1100/2012/303654.

• Scardovi AB, De Maria R, Ferraironi A, Gatto L, Celestini A, Forte S, Parolini M, Sciarretta S, Ricci R, Guazzi M. A case for assessment of oscillatory breathing during cardiopulmonary exercise test in risk stratification of elderly patients with chronic heart failure. Int J Cardiol 2012;155(1):115-19. doi: 10.1016/j.ijcard.2011.02.033. Epub 2011 Mar 13.

• Caruso R, Verde A, Campolo J, Milazzo F, Russo C, Boroni C, Parolini M, Trunfio S, Paino R, Martinelli L, Frigerio M, Parodi O. Severity of oxidative stress and inflammatory activation in end-stage heart failure patients are unaltered after one month of left ventricular mechanical assistance. Cytokine 2012;59:138-doi: 10.1016/j.cyto.2012.04.018.

• Lee M, Zine N, Baraket A, Zabala M, Campabadal F, Caruso R, Trivella MG, Jaffrezic-Renault N, Errachid A. A novel biosensor based on hafnium oxide: Application for early stage detection of human interleukin-10. Sensors and Actuators B: Chemical 2012;175:201–207 doi:10.1016/j.snb.2012.04.090

• Parodi O, Exarchos T, Marraccini P, Vozzi F, Milosevic Z, Nikolic D, Sakellarios A, Siogkas P, Fotiadis DI, Filipovic N. Patient-specific prediction of coronary plaque growth from CTA angiography: a multiscale model for plaque formation and progression. IEEE Trans Inf Technol Biomed 2012;16:952-65. Epub 2012 May 30.

• Cabiati M, Caruso R, Caselli C, Frigerio M, Prescimone T, Parodi O, Giannessi D, Del Ry S. The natriuretic peptide time-course in end-stage heart failure patients supported by left ventricular assist device implant: focus on NT-proCNP. Peptides 2012;Aug 36(2):192-98. doi: 10.1016/j.peptides.2012.05.018. Epub 2012 Jun 5.

• Vecoli C, Caselli C, Caruso R, Morales MA. La malattia del microcircolo coronarico nella disfunzione ventricolare sinistra: dai modelli sperimentali alla clinica. Recenti Prog Med 2012 Jul;103(7):288-96. doi: 10.1701/1127.12433.

• Baraket A, Lee M, Zine N, Yaakoubi N, Trivella MG, Zabala M, Bausells J, Jaffrezic-Renault N, Errachid A. Cytokine Detection using Diazonium Modified Gold Microelectrodes Onto Polyimide Substrates with Integrated Ag/AgCl Reference Electrode. Procedia Engineering 2012;47:1181–84, 26th European Conference on Solid-State Transducers, EUROSENSOR 2012.

• Cabiati M, Sabatino L, Caruso R, Caselli C, Prescimone T, Giannessi D, Del Ry S. Gene expression of C-type natriuretic peptide and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects. Peptides 2012;37(2):240-46. doi: 10.1016/j.peptides.2012.07.026.

• De Maria R, Landolina M, Gasparini M, Schmitz B, Campolo J, Parolini M, Sanzo M, Galimberti P, Bianchi M, Brand SM, Parodi O, Lunati M. Genetic Variants of the Renin-Angiotensin-Aldosterone System and Reverse Remodeling after Cardiac Resynchronization Therapy J Card Fail;2012;18(10):762-68. doi10.1016/j.cardfail.2012.07.008.

• Hartley CJ, Naghavi M, Parodi O, Pattichis CS, Poon CCY, Zhang Y. Guest Editorial on Cardiovascular Health Informatics: Risk Screening and Intervention. IEEE Trans Inf Technol Biomed 2012;16(5):791-94.

• Caruso R, De Chiara B, Campolo J, Verde A, Musca F, Belli O, Parolini M, Cozzi L, Moreo A, Frigerio M, Parodi O. Neopterin levels are independently associated with cardiacin patients with chronic heart failure. Clin Biochem 2013;Jan;46(1-2):94-98. doi: 10.1016/j.clinbiochem.2012.10.022.

• Del Bo C, Riso P, Campolo J, Møller P, Loft S, Klimis-Zacas D, Brambilla A, Rizzolo A, Porrini M. A single portion of blueberry (Vaccinium corymbosum L.) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutr Res 2013;33(3):220-27. doi: 10.1016/j.nutres.2012.12.009. Epub 2013 Feb 1.

• Caruso R, De Chiara B, Campolo J, Verde A, Musca F, Belli O, Parolini M, Cozzi L, Moreo A, Frigerio M, Parodi O. Neopterin levels are independently associated with cardiacin patients with chronic heart failure. Clin Biochem 2013;46:94-98. doi: 10.1016/j.clinbiochem.2012.10.022. Epub 2012 Oct 24.

• Cozzi L, Campolo J, Parolini M, De Maria R, Patrosso MC, Marocchi A, Parodi O, Penco S. Paraoxonase 1 L55M, Q192R and Paraoxonase 2 S311C alleles in atherothrombosis. Mol Cell Biochem 2013;374:233–doi: 10.1007/s11010-012-1525-2. Epub 2012 Dec 6.

• Cabiati M, Caselli C, Caruso R, Prescimone T, Verde A, Botta L, Parodi O, Del Ry S, Giannessi D. High peripheral levels of heart-Fatty Acid binding Protein (h-FABP) are associated to poor prognosis in end-stage heart failure patients with mechanical circulatory support. Biomark Med 2013;7(3):481-92. doi: 10.2217/bmm.13.6.

• Athanasiou LS, Karvelis PS, Sakellarios AI, Exarchos TP, Siogkas PK, Tsakanikas VD, Naka KK, Bourantas CV, Papafaklis MI, Koutsouris G, Michalis LK, Parodi O, Dimitrios I. Fotiadis A hybrid plaque characterization method using intravascular ultrasound images. Technol Health Care 2013;21(3):199-216. doi: 10.3233/THC-130717.

• Filipovic N, Teng Z, Radovic M, Saveljic I, Fotiadis D, Parodi O. Computer simulation of three-dimensional plaque formation and progression in the carotid artery. Med Biol Eng Comput 2013;51(6):607-16. doi: 10.1007/s11517-012-1031-4.

• Sakellarios AI, Papafaklis MI, Siogkas P, Athanasiou LS, Exarchos T, Stefanou K, Bourantas C, Naka KK, Michalis LK, Parodi O, Fotiadis DI. Patient-Specific Computational Modeling of LDL Subendothelial Accumulation in a Stenosed Right Coronary Artery: Effect of Hemodynamic and Biological Factors. Am J Physiol Heart Circ Physiol 2013;Jun 1;304(11):H1455-H1470. doi: 10.1152/ajpheart.00539.2012. Epub 2013 Mar 15.

• Bamonti F, Pellegatta M, Novembrino C, Vigna L, De Giuseppe R, de Liso F, Gregori D, Della noce C, Patrini L, Schiraldi G, Bonara P, Calvelli L, Maiavacca R, Cighetti G. An Encapsulated Juice Powder Concentrate Improves Markers of Pulmonary Function and Cardiovascular Risk Factors in Heavy Smokers. JACN 2013; 32(1):18-25. doi: 10.1080/07315724.2013.767652.

• Melaiou O, Facioni MS, Cabiati M, Caruso R, Giannessi D, Landi S, Gemignani F, Del Ry S. Characterization of novel 3’untranslated regions and related polymorphisms of the gene NPPC, encoding for the C-type natriuretic peptide. Peptides 2013;44:93-99. doi: 10.1016/j.peptides.2013.03.012. Epub 2013 Mar 28.

• Caselli C, D’Amico A, Caruso R, Cabiati M, Prescimone T, Cozzi L, Cannata A, Parodi O, Del Ry S, Giannessi D.. Evaluation of reference genes in different myocardial regions after Left Ventricular Assist Device support: expression of pro-inflammatory cytokines. Cytokine 2013;63:113–22. doi: 10.1016/j.cyto.2013.04.021. Epub 2013 May 10.

• Campolo J, De Maria R, Mariotti C, Tomasello C, Frontali M, Inzitari D, Valenti R, Federico A, Taroni F, Parodi O. Is the Oxidant/Antioxidant Status Altered in CADASIL Patients? PLOS One 2013;8(6):e67077. doi:10.1371/journal.pone.0067077.

• Cabiati M, Caruso R, Verde A, Sabatino L, Morales M-A, Del Ry S. Transcriptomic profiling of the four adenosine receptors in human leukocytes of heart failure patients. Biomed Res Int 2013;2013:569438. doi: 10.1155/2013/569438. Epub 2013 Jul 8.

• Cabiati M, Sabatino L, Caruso R, Verde A, Caselli C, Prescimone T, Giannessi D, Del Ry S.. C-type natriuretic peptide transcriptomic profiling increases in human leukocytes of patients with chronic heart failure as a function of clinical severity.2013;Sep;47:110-14. doi: 10.1016/j.peptides.2013.07.019. Epub 2013 Jul 30.

• Baraket A, Lee M, Zine N, Sigaud M, Yaakoubi N, Trivella MG, Zabala M, Bausells J, Jaffrezic-Renault N, Errachid A. Diazonium modified gold microelectodes onto polyimide substrates for impedimetric cytochine detection with an integrated Ag/AgCl reference electrode. Sensors and Actuators B: Chemical 2013;189:165–72.

• Riso P, Vendrame S, Del Bò C, Martini D, Martinetti A, Seregni E, Visioli F, Parolini M, Porrini M. Effect of 10-day broccoli consumption on inflammatory status of young healthy smokers. Int J Food Sci Nutr 2014;65(1):106-11. doi: 10.3109/09637486.2013.830084.

• Della noce C, Cozzi L, Zuddas S, Pratali L, Accinni R. Determination of different forms of aminothiols in Red Blood Cell without washing erythrocytes. Biomed Chormatogr 2014;28(3):327-31. doi: 10.1002/bmc.3056. Epub 2013 Oct 17.

• Caselli C, D'Amico A, Ragusa R, Caruso R, Prescimone T, Cabiati M, Nonini S, Marraccini P, Del Ry S, Trivella MG, Parodi O, Giannessi D. IL-33/ST2 pathway and classical cytokines in end stage heart failure patients submitted to left ventricular assist device support: a paradoxic role for inflammatory mediators? Mediators2013;2013:498703. doi: 10.1155/2013/498703. Epub 2013 Dec 10.

• Iacovoni A, De Maria R, Gavazzi A, Grosu A, Fontana A, Guideri S, Gori M, Ferrari P, Filippi A, Rutili MR, Donzelli L, Parolini M, Senni M. Natriuretic peptides and the Framingham Risk score for screening of asymptomatic left ventricular systolic dysfunction in high-risk patients in primary care. The DAVID-BERG study. Int J Cardiol 2013;168(5):5093-doi: 10.1016/j.ijcard.2013.07.260.

• Rubino FM, Dellanoce C, Vigna L, De Giuseppe R, Novembrino C, de Liso F, Maiavacca R, Patrini L, Ribaldi L, Bamonti F. Measurement of Glutathionylated Haemoglobin by MALDI-ToF Mass Spectrometry as a Biomarker of Oxidative Stress in Heavy Smokers and in Occupational Obese Subjects IJA MSC 2013;1:22-30.

• Lee M, Zine N, Baraket A, Zabala M, Campabadal F, Caruso R, Trivella MG, Jaffrezic-Renault N, Errachid A. A novel three-dimensional biosensor based on aluminum oxide: application for early-stage detection of human interleukin-10. Methods Mol Biol 2014;1172:49-64. doi: 10.1007/978-1-4939-0928-5_5.

• Riso P, Klimis-Zacas D, Del Bo' C, Martini D, Campolo J, Vendrame S, Moller P, Loft S, De Maria R, Porrini M. Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur J Nutr 2013;52:949-61. doi: 10.1007/s00394-012-0402-9. Epub 2012 Jun 26.

• Athanasiou LS, Karvelis PS, Sakellarios AI, Exarchos TP, Siogkas PK, Tsakanikas VD, Naka KK, Bourantas CV, Papafaklis MI, Koutsouris G, Michalis LK, Parodi O, and Dimitrios I. Fotiadis A hybrid plaque characterization method using intravascular ultrasound images. Technol Health Care 2013;21(3):199-216. doi: 10.3233/THC-130717.

• Riso P, Vendrame S, Del Bo' C, Martini D, Martinetti A, Seregni E, Visioli F, Parolini M, Porrini M. Effect of 10-day broccoli consumption on inflammatory status of young healthy smokers. Int J Food Sci Nutr 2014;65:106-11. doi: 10.3109/09637486.2013.830084. Epub 2013 Sep 2.

• Campolo J, Vozzi F, Penco S, Cozzi L, Caruso R, Domenici C, Ahluwalia A, Rial M, Marraccini P, Parodi O. Vascular injury post stent implantation: different gene expression modulation in HUVECs model. PLoS One 2014;9(2):doi: 10.1371/journal.pone.0090213. eCollection 2014.

• Dellanoce C, Cozzi L, Zuddas S, Pratali L, Accinni R. Determination of different forms of aminothiols in red blood cells without washing erythrocytes. Biomed Chromatogr 2014;28:327-31. doi: 10.1002/bmc.3056. Epub 2013 Oct 17.

• Fresiello L, Zielinski K, Jacobs S, Di Molfetta A, Palko KJ, Bernini F, Martin M, Ferrari G, Trivella MG, Gorczynska K, Darowski M, Meyns B, Kozarski M. Reproduction of Continuous Flow Left Ventricular Assist Device Experimental Data by Means of a Hybrid Cardiovascular Model With Baroreflex Control Artif2014 Jun;38(6):456-68. doi: 10.1111/aor.12178. Epub 2013 Oct 1.

• Karvounis E, Tsipouras M, Tzallas A, Katertsidis N, Stefanou K, Goletsis Y, Frigerio M, Verde, A, Caruso, R, Meyns B, Terrovitis J, Trivella M, Fotiadis D. A Decision Support System for the treatment of patients receiving Ventricular Assist Device Support. Methods Inf Med 2014;53:121-36. doi: 10.3414/ME13-01-0047. Epub 2014 Feb 27.

• Baraket A, Lee M, Zine N, Yaakoubi N, Trivella MG, Elaissari A, Sigaud M, Jaffrezic-Renault N, Errachid A. A Flexible Label-Free Biosensor Sensitive and Selective to TNF-alpha: Application for Chronic Heart Failure. Sensors & Transducers 2014; Special Issue, 27:15-21.

• Tzallas AT, Katertsidis NS, Karvounis EC, Tsipouras MG, Rigas G, Goletsis Y, Zielinski K, Fresiello L, Molfetta AD, Ferrari G, Terrovitis JV, Trivella MG, Fotiadis DI. Modeling and simulation of speed selection on left ventricular assist devices. Comput Biol Med 2014;51:128-39. doi: 10.1016/j.compbiomed.2014.04.013. Epub 2014 May 9.

• Cabiati M, Sabatino L, Svezia B, Caruso R, Verde A, Caselli C, Prescimone T, Giannessi D, Silvia Dr. Adrenomedullin and intermedin gene transcription is increased in leukocytes of patients with chronic heart failure at different stages of the disease. Peptides 2014;55:13-16. doi: 10.1016/j.peptides.2014.01.028. Epub 2014 Feb 14.

• Schmitz B, De Maria R, Gatsios D, Chrysanthakopoulou T, Landolina M, Gasparini M, Campolo J, Parolini M, Sanzo A, Galimberti P, Bianchi M, Lenders M, Brand E, Parodi O, Lunati M, Brand SM. Identification of Genetic Markers for Treatment Success in Heart Failure Patients: Insight from Cardiac Resynchronization Therapy. Circ Cardiovasc Genet 2014;Dec;7(6):760-70. doi: 10.1161/CIRCGENETICS.113.000384. Epub 2014 Sep 10.

• Verbeni A, Fontana R, Silvestri M, Tortora G, Vatteroni M, Trivella MG, Dario P. An innovative adaptive control strategy for sensorized left ventricular assist devices. IEEE Trans Biomed Circuits Syst. 2014 Oct;8(5):660-8. doi: 10.1109/TBCAS.2014.2346015. Epub 2014 Sep 11.

• Caruso R, Botta L, Verde A, Milazzo F, Vecchi I, Trivella MG, Martinelli L, Paino R, Frigerio M, Parodi O. Relationship between pre-implant interleukin-6 levels, inflammatory response, and early outcome in patients supported by left ventricular assist device: a prospective study. PLoS One 2014;9:e90802. doi: 10.1371/journal.pone.0090802. eCollection 2014.

• Prescimone T, Masotti S, D'Amico A, Caruso R, Cabiati M, Caselli C, Viglione F, Verde A, Del Ry S, Giannessi D. Cardiac molecular markers of programmed cell death are activated in end-stage heart failure patients supported by left ventricular assist device. Cardiovasc Pathol 2014;23:272-82. doi: 10.1016/j.carpath.2014.04.003. Epub 2014 Apr 13.

• Gavazzi A, De Maria R, Grosu A, Iacovoni A, Fontana A, Gori M, Ferrari P, Canova P, Calabrese A, Filippi A, Rutili MR, Donzelli L, Parolini M, Senni M. Screening of asymptomatic left ventricular systolic dysfunction in a population sample at high cardiovascular risk in Lombardy (Italy): the DAVID-Berg study. G Ital Cardiol 2014;15:313-22. doi: 10.1714/1563.17033.

• De Maria R, Campolo J, Frontali M, Taroni F, Federico A, Inzitari D, Tafani A, Romano S, Puca E, Orzi F, Francia A, Mariotti C, Tomasello C, Dotti MT, Stromillo ML, Pantoni L, Pescini F, Valenti R, Pelucchi C, Parolini M, Parodi O. Effects of sapropterin on endothelium-dependent vasodilation in patients with CADASIL: a randomized controlled trial. Stroke 2014;45:2959-2966. doi: 10.1161/STROKEAHA.114.005937. Epub 2014 Sep 2.

• Caruso R, Campolo J, Verde A, Botta L, Cozzi L, Parolini M, Milazzo F, Nonini S, Martinelli L, Paino R, Marraccini P, Frigerio M. Relationship between Early Inflammatory Response and Clinical Evolution of the Severe Multiorgan Failure in Mechanical Circulatory Support-Treated Patients. Mediators Inflamm 2014;2014:281790. doi: 10.1155/2014/281790. Epub 2014 Jul 14.

• Del Bo' C, Porrini M, Fracassetti D, Campolo J, Klimis-Zacas D, Riso P. A single serving of blueberry (V. corymbosum) modulates peripheral arterial dysfunction induced by acute cigarette smoking in young volunteers: a randomized-controlled trial. Food Funct 2014;5(12):3107-16. doi: 10.1039/c4fo00570h.

• Caruso R, Caselli C, Cozzi L, Campolo J, Viglione F, Parolini M, Nonini S, Trunfio S, D’Amico A, Pelosi G, Giannessi D, Marraccini P, Frigerio M, Parodi O. Myocardial interleukin-6 in the setting of left ventricular mechanical assistance: relation with outcome and C-reactive protein. Clin Chem Lab Med 2015;Aug;53(9):1359-66. doi: 10.1515/cclm-2014-0633.

• D’Amico A, Ragusa R, Caruso R, Prescimone T, Nonini S, Cabiati M, Del Ry S, Trivella M G, Giannessi D, Caselli C. Uncovering the cathepsin system in heart failure patients submitted to Left Ventricular Assist Device (LVAD) implantation. J Transl Med 2014;12;12:350. doi: 10.1186/s12967-014-0350-7.

• Comassi M, Vitolo E, Pratali L, Del Turco S, Dellanoce C, Rossi C, Santini E, Solini A. Acute effects of different degrees of ultra-endurance exercise on systemic inflammatory responses. Intern Med J 2015;45(1):74-9. doi: 10.1111/imj.12625.

• Barsanti C, Trivella MG, D’Aurizio R, El Baroudi M, Baumgart M, Groth M, Caruso R, Verde A, Botta L, Cozzi, L and Pitto L. Differential Regulation of MicroRNAs in End-Stage Failing Hearts Is Associated with Left Ventricular Assist Device Unloading. Biomed Res2015;2015:592512. doi: 10.1155/2015/592512. Epub 2015 Feb 1.

• Fresiello L, Trivella MG, Di Molfetta A, Ferrari G, Bernini E, Meste O. The Relationship Between R-Wave Magnitude and Ventricular Volume During Continuous Left Ventricular Assist Device Assistance: Experimental Study. Artif2015 May;39(5):446-50. doi: 10.1111/aor.12407. Epub 2014 Nov 6.

• Prescimone T, D'Amico A, Caselli C, Cabiati M, Viglione F, Caruso R, Verde A, Del Ry S, Trivella MG, Giannessi D. Caspase-1 transcripts in failing human heart after mechanical unloading. Cardiovasc Pathol 2015;24(1):11-doi: 10.1016/j.carpath.2014.08.002. Epub 2014 Aug 12.

• Caruso R, Rochiccioli S, Gori AM, Cecchettini A, Giusti B, Parodi G, Cozzi L, Marcucci R, Parolini M, Romagnuolo I, Citti L, Abbate R, Parodi O. Inflammatory and Antioxidant Pattern Unbalance in “Clopidogrel-Resistant” Patients During Acute Coronary Syndrome. Mediators of inflammation. Mediators Inflamm 2015;2015:710123. doi: 10.1155/2015/710123. Epub 2015 Mar 19.

• Fresiello L, Ferrari G, Di Molfetta A, Zieliński K, Tzallas A, Jacobs S, Darowski M, Kozarski M, Meyns B, Katertsidis NS, Karvounis EC, Tsipouras MG, Trivella MG. A cardiovascular simulator tailored for training and clinical uses. J Biomed Inform. 2015 Jul 11. pii: S1532-0464(15)00144-6. doi: 10.1016/j.jbi.2015.07.004. [Epub ahead of print]

• Mrakic-Sposta S, Gussoni M, Moretti S, Pratali L, Giardini G, Tacchini P, Dellanoce C, Tonacci A, Mastorci F, Borghini A, Montorsi M, Vezzoli A. Effects of mountain ultra-marathon running on ROS production and oxidative damage by micro-invasive analytic techniques. PLOS ONE 2015; Nov 5,10(11):e0141780 – doi 10.1371/journal.pone.0141780

• Trivella MG, Tonacci A, Billeci L, Gemignani V, Gastaldelli A, Gemignani A. Neurophysiological and Behavioural Variables in Cognitive Impairment: Towards a Personalised Monitoring System. In Springer International Publishing Switzerland 2015 ISBN 978-3-319-18374-9, 2015, B. Andò et al. (eds.), Ambient Assisted Living, Biosystems & Biorobotics, pp 407-417. doi 10.1007/978-3-319-18374-9_38

• Bussiere A, Cardot JM, Beretta A, Dellanoce C, Accinni R. Efficacy of standardized extract of prunus mume in liver protection and redox homeostasis: a randomized, double-blind, placebo-controlled study. Phytother Res 2016; Mar 8. doi: 10.1002/ptr.5597.

• Del Bo' C, Porrini M, Campolo J, Parolini M, Lanti C, Klimis-Zacas D, Riso P. A single blueberry (Vaccinium corymbosum) portion does not affect markers of antioxidant defence and oxidative stress in healthy volunteers following cigarette smoking.Mutagenesis 2016;Mar 31(2):215-24. doi: 10.1093/mutage/gev079. Epub 2015 Nov 23.

• Vozzi F, Guerrazzi I, Campolo J, Cozzi L, Comelli L, Cecchettini A, Rochiccioli S, Domenici C. Biological and Proteomic characterization of a composite mesh for abdominal wall hernia treatment: Reference Study. J Biomed Mater Res B Appl Biomater. 2016 Jul 8. doi: 10.1002/jbm.b.

• Vigna L, Fenoglio C, Bamonti F, Novembrino C, De Giuseppe R, Dellanoce C, Coassin L, Cighetti G, Maiavacca R, Gregori D. Altered gender-related homocysteine metabolism and lipid panel in healthy heavy smokers. A possible role for nutraceutical supplementation. Nutrafoods 2016;15:245-261 doi 10.17470/NF-016-1010-4.

• Vezzoli A, Dellanoce C,Mrakic-Sposta S, Montorsi M, Moretti S, Tonini A, Pratali L, Accinni R.Oxidative stress assessment in response to ultra-endurance exercise: thiols redox status and ros production in according to dutation of competitive race. Oxidative Medicine and Cellular; doi:10.1155/2016/6439037.

• Del Bo’C, Deon V, PorriniM, Campolo J, ParoliniM, Riso P. Intra and inter-day repeatability of peripheral arterial function: suitability and potential limitations. Microcirculation. Microcirculation. 2016, 23:503–511.Jul 22. doi: 10.1111/micc.12300.

• Campolo J, De Maria R, Cozzi L, Parolini M, Bernardi S, Proserpio P, Nobili L, Gelosa G, Piccolo I, Agostoni EC, Trivella MG, Marraccini P. Antioxidant and inflammatory biomarkers for the identification of prodromal Parkinson’s disease. J Neurol Science Journal of the Neurological Sciences 370 (2016) 167–172. doi: 10.1016/j.jns.2016.09.050.

• De Giuseppe R, Venturelli G, Guez S, Salera S, De Vita C, Consonni D, Dellanoce C, Bamonti F, Chiarelli G, Manzoni F, Maiavacca R, Esposito S. Homocysteine metabolism in children and adolescents with epidermolysis bullosa. BMC PEDIATRICS (2016) 16:173DOI 10.1186/s12887-016-0714-7.

• Fontana R, Tortora G, Silvestri M, Vatteroni M, Dario P, Trivella MG. A portable system for autoregulation and wireless control of sensorized left ventricular assist devices. Biocybernetics and Biomedical Engineering 2016;36(2),366–74.

• Kourou K, Rigas G, Exarchos KP, Goletsis Y, Exarchos TP, Jacobs S, Meyns B, Trivella MG, Fotiadis DI. Prediction of time dependent survival in HF patients after VAD implantation using pre- and post-operative data. Comput Biol Med. 2016 Mar 1;70:99-105. doi: 10.1016/j.compbiomed.2016.01.005. Epub 2016 Jan 12.

• Di Tano G, Caretta G, De Maria R, Parolini M, Bassi L, Testa S, Pirelli S. Galectin-3 predicts left ventricular remodelling after anterior-wall myocardial infarction treated by primary percutaneous coronary intervention. Heart. 2017 Jan 1;103(1):71-77. doi: 10.1136/heartjnl-2016-309673. Epub 2016 Jul 27.

• Campolo J, Bernardi S, Cozzi L, Rocchiccioli S, Dellanoce C, Cecchettini A, Tonini A, Parolini M, De Chiara B, Micheloni G, Pelosi G, Giannattasio C, Parodi O. Medium-term effect of sublingual L-glutathione (L-GSH) supplementation on flow-mediated dilation in subjects with cardiovascular risk factors. Nutrition 2017;38:41–47. http://dx.doi.org/10.1016/j.nut.2016.12.018.

• Baraket A, Lee M, Zine N, Caruso R, Trivella MG, Errachid A. Electrochemical Biosensor for Interleukin-10 Detection in Real Human Plasma Patients: Heart Failure Biomedical Application. Int J Cardiovasc Res 2017;6:1. doi: 10.4172/2324-8602.1000294

Patents:

Method for separating the constituents of a complex mixture of proteins to submit to proteomic analysis and apparatus therefore. Priority IT/29.09.08/ITA PI20080102. Data of filing 29/09/09.

METODO PER VALUTARE LA PROGNOSI DI UN PAZIENTE AFFETTO DA SCOMPENSO CARDIACO Patent pending ITPI2011A000080 Data di deposito: 15 luglio 2011. Data di concessione 21/3/2014. Numero concessione 0001407074. Classificazione G06F 19/00.

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In auto

In uscita dall’autostrada A4 (TO-VE) percorrere la tangenziale ovest fino all’uscita di Cormano; dall’uscita di Cormano seguire le indicazioni per Centro città – Niguarda.

Dalla Stazione ferroviaria “Milano Centrale”

Prendere la metropolitana linea 3 (“gialla”) in direzione Maciachini; scendere alla fermata di Maciachini e prendere il tram 4 in direzione Niguarda; scendere alla fermata Ospedale Maggiore, situata davanti all’ingresso dell’Ospedale.

Dalla Stazione ferroviaria “Garibaldi”

Prendere la metropolitana linea 2 (“verde”) in direzione Gessate/Cologno fino alla fermata di Centrale F.S.; alla fermata di Centrale F.S. prendere la linea 3 (“gialla”) in direzione Maciachini; scendere alla fermata di Maciachini e prendere il tram 4 in direzione Niguarda; scendere alla fermata Ospedale Maggiore, situata davanti all’ingresso dell’Ospedale.

Dall’aeroporto di Malpensa

Prendere il bus (Malpensa Shuttle) che ferma a Milano, presso la Stazione ferroviaria “Milano Centrale”. Dalla Stazione, prendere la metropolitana linea 3 (“gialla”) in direzione Maciachini; scendere alla fermata di Maciachini e prendere il tram 4 in direzione Niguarda; scendere alla fermata Ospedale Maggiore, situata davanti all’ingresso dell’Ospedale.

Prendere il treno “Malpensa Express” che ferma a Milano, presso la Stazione ferroviaria “Cadorna”. Dalla Stazione, prendere la metropolitana linea 2 (“verde”) in direzione Gessate/Cologno fino alla fermata di Centrale F.S.; alla fermata di Centrale F.S. prendere la linea 3 (“gialla”) in direzione Maciachini; scendere alla fermata di Maciachini e prendere il tram 4 in direzione Niguarda; scendere alla fermata Ospedale Maggiore, situata davanti all’ingresso dell’Ospedale